Are there domains that shouldn't be enabled with CloudFlare?
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An orange cloud means that your web traffic will pass through the CloudFlare system making your site Faster, Safer and Smarter. A gray cloud means that your traffic will not pass through the CloudFlare system.
Only CNAME records have the option to be powered by CloudFlare, meaning that only CNAME records have the option of an orange cloud. However, not all CNAME records are appropriate to pass through the CloudFlare system.
To decide which records pass through the CloudFlare network, you need to understand what type of content appears on that subdomain. You should enable CloudFlare for any subdomain that gets web traffic. You should not enable CloudFlare for subdomains that handle non-web traffic, such as mail and ftp. These types of records should be marked by a gray cloud.